Article

HMGB1 mediates macrophage recruitment and regional intervertebral disc tissue functional and mechanical property changes following injury

2024-11-03

Abstract excerpt

<h4>Objective</h4> Frequently evaluated in musculoskeletal disease, damage associated molecular patterns (DAMPs) respond to tissue damage and cellular stress by facilitating an inflammatory response via macrophage activation and broad inflammatory pathway activation. In the context of disc degeneration (DD), high mobility group box 1 (HMGB1), a potent intracellular DAMP, is seen to be increased within severely de...

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Literature Corpus work: fdf805c5-5152-55e6-a3b0-c98e7722e0f3
DOI: 10.1101/2024.10.30.621107

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