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Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

26 Jun 2025

Abstract excerpt

Abstract Inflammation is a hallmark of intervertebral disc degeneration (IVDD) characterized by immune cell infiltration and cytokine secretion. Stage‐specific transcriptomic analyses of IVDD via single‐cell RNA sequencing (scRNA‐seq) have primarily focused on nucleus pulposus cell phenotypes but not immune subpopulations. In other disease contexts, integrating genome‐wide association studies (GWAS) with...

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PMID: 40570207
DOI: 10.1002/advs.202500505

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