Article

OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies

2025-01-12

Abstract excerpt

Optineurin (OPTN) is a crucial component of the homeostatic pathway, playing a pivotal role in regulating a number of essential signaling pathways including NF-κB, interferon, autophagy, and vesicular trafficking. The dysfunction of OPTN has been implicated in the pathogenesis of several diseases, such as primary open angle glaucoma (POAG), amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia, and Pa...

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Literature Corpus work: 430856f4-fc8d-5a26-8bfc-b4526ba3636f
DOI: 10.1101/2025.01.09.632264

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