Article

Proteomic Comparison of Aged and OPTN E50K Retina in The Development of Normal Tension Glaucoma

2021-02-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Progressive degeneration of retinal ganglion cells (RGCs) is a major characteristic of glaucoma, whose underlying mechanisms are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal tension glaucoma (NTG), directly affecting RGCs without high intraocular pressure and causing severe glaucomatous symptoms in clinical s...

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Literature Corpus work: 1f399cc6-e736-5c1b-840b-4150d3a59b7e
DOI: 10.21203/rs.3.rs-179540/v1

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