Article

Proteomic Comparison of Aged and OPTN E50K Retina in the Development of Normal Tension Glaucoma

2021-01-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Progressive degeneration of retinal ganglion cells (RGCs) is a major characteristic of glaucoma, whose underlying mechanisms are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal tension glaucoma (NTG), directly affecting RGCs without high intraocular pressure and causing severe glaucomatous symptoms in clinical s...

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Literature Corpus work: b8f8094c-549c-523f-8d08-1d42f0146e68
DOI: 10.21203/rs.3.rs-141353/v1

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