Article
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells.
Stem cell reports - 12 Jul 2022
Gomes Cátia, VanderWall Kirstin B, Pan Yanling, Lu Xiaoyu, Lavekar Sailee S, Huang Kang-Chieh, Fligor Clarisse M, Harkin Jade, Zhang Chi, Cummins Theodore R, Meyer Jason S
Abstract excerpt
Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although studies often explore cell-autonomous aspects of RGC neurodegeneration, a more comprehensive model of glaucoma should take into consideration interactions between astrocytes and RGCs. To explore this concept, RGCs and astrocytes were...
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