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Article

Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.

Human molecular genetics - 31 May 2021

Liu Xinna, Wang Qi, Shao Zhengbo, Zhang Shiqi, Hou Mingying, Jiang Menglu, Du Mengxian, Li Jing, Yuan Huiping

Abstract excerpt

Progressive degeneration of retinal ganglion cells (RGCs) is a major characteristic of glaucoma, whose underlying mechanisms are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal tension glaucoma (NTG), directly affecting RGCs without high intraocular pressure and causing severe glaucomatous symptoms in clinical settings. A systematic analysis of the NTG mouse...

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PMID: 33856034
DOI: 10.1093/hmg/ddab099

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Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.PMID 33856034Read ↗

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