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Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.

Stem cell reports - 14 Jul 2020

VanderWall Kirstin B, Huang Kang-Chieh, Pan Yanling, Lavekar Sailee S, Fligor Clarisse M, Allsop Anna R, Lentsch Kelly A, Dang Pengtao, Zhang Chi, Tseng Henry C, Cummins Theodore R, Meyer Jason S

Abstract excerpt

Retinal ganglion cells (RGCs) serve as the connection between the eye and the brain, with this connection disrupted in glaucoma. Numerous cellular mechanisms have been associated with glaucomatous neurodegeneration, and useful cellular models of glaucoma allow for the precise analysis of degenerative phenotypes. Human pluripotent stem cells (hPSCs) serve as powerful tools for studying human disease, particularly...

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Identifiers

PMID: 32531194
DOI: 10.1016/j.stemcr.2020.05.009
PMCID: PMC7363877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.PMID 32531194Read ↗

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