Article

Proteomic and Genomic Signatures of Repeat-instability in Cancer and Adjacent Normal Tissues

2018-12-09

Abstract excerpt

<h4>Summary</h4> Repetitive sequences are hotspots of evolution at multiple levels. However, due to technical difficulties involved in their assembly and analysis, the role of repeats in tumor evolution is poorly understood. We developed a rigorous motif-based methodology to quantify variations in the repeat content of proteomes and genomes, directly from proteomic and genomic raw sequence data, and applied it to...

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Literature Corpus work: 430855e8-8f02-56e7-afb0-5cc61f60aa6e
DOI: 10.1101/491423

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