Article

A genome-wide atlas of recurrent repeat expansions in human cancer

2022-08-24

Abstract excerpt

Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to cause more than 50 diseases. However, repeat expansions are often not explored beyond neurological and neurodegenerative disorders. In some cancers, mutations accumulate in short tracts of TRs (STRs), a phenomenon termed microsatellite instability (MSI); however larger repeat expansions have not been systematically analyzed in...

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Literature Corpus work: 1db0fbc5-635a-586b-bc99-af8e83bfb40b
DOI: 10.1101/2022.08.24.505159

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