Article

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteria

2018-04-08

Abstract excerpt

The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successful infection. Using transcriptome sequencing, we found that the abrogation of ESX-1 function in Mycobacterium marinum leads to a pronounced increase in gene expressio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59fde16c-efab-5333-8d20-5c43d449e603
DOI: 10.1101/297440

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaDOI 10.1101/297440Read

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read

WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinumSemantic proximity Read

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read

Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinumSemantic proximity Read

The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinumSemantic proximity Read

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspFSemantic proximity Read

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinumSemantic proximity Read

A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.Semantic proximity Read

Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 systemSemantic proximity Read

The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in <i>M. marinum</i>Semantic proximity Read

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read

Conserved ESX-1 Substrates EspE and EspF Are Virulence Factors That Regulate Gene ExpressionSemantic proximity Read