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Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinum

7 Jun 2022

Abstract excerpt

The ESX-1 (ESAT-6-system-1) system and the protein substrates it transports are essential for mycobacterial pathogenesis. The precise ways that ESX-1 substrates contribute to virulence remains unknown. Several known ESX-1 substrates are also required for the secretion of other proteins. We used a proteo-genetic approach to construct high-resolution dependency relationships for the roles of individual ESX-1...

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PMID: 35671426
DOI: 10.1073/pnas.2123100119

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Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinumPMID 35671426Read ↗

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