Article

Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase

2020-10-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) <italic>in vitro</italic> would be useful for drug discovery and cell therapy in diabetes. Three-dimensional (3D) culture is important for the acquisition of mature insulin-producing cells from hPSCs, but the mechanism by which it promotes β cell maturation is poorly understood.<bold...

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Literature Corpus work: 42ff19b6-5c83-57fa-8371-c1578bd2460f
DOI: 10.21203/rs.3.rs-33692/v3

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