Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

12 Apr 2022

Abstract excerpt

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as diabetes treatment. Despite recent progress, efforts to generate physiologically competent β-cells are still hindered by incomplete understanding of the microenvironment's role in β-cell development and maturation. Here, we analyze the human mesenchymal and endothelial primary cells from weeks 9-20 fetal pancreas and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Diabetes Management and Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35414140
DOI: 10.1038/s41467-022-29646-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signalingPMID 35414140Read ↗

Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoidsSemantic proximity Read ↗

Transcription factors that shape the mammalian pancreasSemantic proximity Read ↗

Single cell transcriptomic and spatial landscapes of the developing human pancreasSemantic proximity Read ↗

The endocrine pancreas: insights into development, differentiation, and diabetesSemantic proximity Read ↗

A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansionSemantic proximity Read ↗

A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansionSemantic proximity Read ↗

Single-cell transcriptomic and spatial landscapes of the developing human pancreasSemantic proximity Read ↗

Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth FactorSemantic proximity Read ↗

A model for angiogenesis suppression via SERPINF1 in the surrounding pro-acinar microenvironment during human fetal pancreas developmentSemantic proximity Read ↗

Dual Inhibition of BMP and WNT Signals Promotes Pancreatic Differentiation from Human Pluripotent Stem CellsSemantic proximity Read ↗

A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.Semantic proximity Read ↗

Human pancreatic islet-derived stromal cells reveal combined features of mesenchymal stromal cells and pancreatic stellate cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.