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Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase

16 Nov 2020

Abstract excerpt

BACKGROUND: Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes. Three-dimensional (3D) culture is important for the acquisition of mature insulin-producing cells from hPSCs, but the mechanism by which it promotes β cell maturation is poorly understood. METHODS: We established a stepwise method to induce...

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PMID: 33198821
DOI: 10.1186/s13287-020-02003-z

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