Article

Waves of transcription drive erythroid differentiation and launch the NRF2-activated antioxidant program

2024-07-16

Abstract excerpt

Transcriptional reprogramming drives differentiation and coordinates cellular responses. While mRNA expression in distinct cell types has been extensively analyzed, the mechanisms that control RNA synthesis upon lineage specifications remain unclear. Here, we induce erythroid differentiation in human cells, track transcription and its regulation at nucleotide-resolution, and identify molecular mechanisms that orch...

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Literature Corpus work: 42f3ff04-52b8-58da-9716-86f3d51e0f78
DOI: 10.1101/2024.07.12.603281

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