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Article

NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors

4 May 2017

Abstract excerpt

Sickle cell disease (SCD) is an inherited blood disorder resulting from an A to T mutation in codon 6 of the β-globin gene leading to hemoglobin S synthesis which undergoes polymerization under low oxygen conditions. Among different treatment strategies investigated in the field, reactivation of

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Identifiers

PMID: 28473619
DOI: 10.3324/haematol.2016.160788

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