Article

Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation

2026-05-30

Abstract excerpt

<h4>Summary</h4> Insulinomas are rare and benign human pancreatic adenomas that overproduce insulin and display increased beta cell mass. We and others have shown that transcriptomic and genomic profiling on insulinomas provides a data mine for identifying targets that can be manipulated to induce human beta cell regeneration. Majority of causative genetic variants in insulinomas involve epigenetic regulatory gen...

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Literature Corpus work: 42ece998-2a5f-5b38-8f02-02e2cdafa850
DOI: 10.64898/2026.05.29.728759

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