Article

Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression

2020-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Recent data suggest that Pancreatic Neuroendocrine Tumours (PanNETs) originate from α- or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not express cell-type specific hormones. We examined whether tumour DNA methylation (DNAme) profiling combined with genomic data could identify cell of origin and reveal pathways involved in PanNET progression. We analyse...

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Literature Corpus work: dd72f394-7fda-5fd4-a74a-17f8ac9087e3
DOI: 10.1101/2020.04.08.029785

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