Article
Implications of noncoding regulatory functions in the development of insulinomas.
Cell genomics - 14 Aug 2024
Ramos-Rodríguez Mireia, Subirana-Granés Marc, Norris Richard, Sordi Valeria, Fernández Ángel, Fuentes-Páez Georgina, Pérez-González Beatriz, Berenguer Balaguer Clara, Raurell-Vila Helena, Chowdhury Murad, Corripio Raquel, Partelli Stefano, López-Bigas Núria, Pellegrini Silvia, Montanya Eduard, Nacher Montserrat, Falconi Massimo, Layer Ryan, Rovira Meritxell, González-Pérez Abel, Piemonti Lorenzo, Pasquali Lorenzo
Abstract excerpt
Insulinomas are rare neuroendocrine tumors arising from pancreatic β cells, characterized by aberrant proliferation and altered insulin secretion, leading to glucose homeostasis failure. With the aim of uncovering the role of noncoding regulatory regions and their aberrations in the development of these tumors, we coupled epigenetic and transcriptome profiling with whole-genome sequencing. As a result, we...
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