Article
A consensus-based classification workflow to determine genetically inferred ancestry from comprehensive genomic profiling of patients with solid tumors.
Briefings in bioinformatics - 23 Sept 2024
Wallen Zachary D, Nesline Mary K, Pabla Sarabjot, Gao Shuang, Vanroey Erik, Hastings Stephanie B, Ko Heidi, Strickland Kyle C, Previs Rebecca A, Zhang Shengle, Conroy Jeffrey M, Jensen Taylor J, George Elizabeth, Eisenberg Marcia, Caveney Brian, Sathyan Pratheesh, Ramkissoon Shakti, Severson Eric A
Abstract excerpt
Disparities in cancer diagnosis, treatment, and outcomes based on self-identified race and ethnicity (SIRE) are well documented, yet these variables have historically been excluded from clinical research. Without SIRE, genetic ancestry can be inferred using single-nucleotide polymorphisms (SNPs) detected from tumor DNA using comprehensive genomic profiling (CGP). However, factors inherent to CGP of tumor DNA...
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