Article
Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.
Cell reports - 26 Jul 2016
Sato Shingo, Tang Yuning J, Wei Qingxia, Hirata Makoto, Weng Angela, Han Ilkyu, Okawa Atsushi, Takeda Shu, Whetstone Heather, Nadesan Puvindran, Kirsch David G, Wunder Jay S, Alman Benjamin A
Abstract excerpt
The cell of origin for most mesenchymal tumors is unclear. One cell type that contributes to this lineages is the pericyte, a cell expressing Ng2/Cspg4. Using lineage tracing, we demonstrated that bone and soft tissue sarcomas driven by the deletion of the Trp53 tumor suppressor, or desmoid tumors driven by a mutation in Apc, can derive from cells expressing Ng2/Cspg4. Deletion of the Trp53 tumor suppressor gene...
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