Article
Jagged1/Notch3 Signaling Modulates Hemangioma-Derived Pericyte Proliferation and Maturation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2016
Ji Yi, Chen Siyuan, Xiang Bo, Li Yuan, Li Li, Wang Qi
Abstract excerpt
BACKGROUND: The Notch signaling pathway has been implicated in the pericyte phenotype, but its exact roles in hemangioma-derived pericytes (Hem-pericytes) remain ill defined. METHODS: Hem-pericytes were stimulated by immobilized recombinant Jagged1. The potential mechanisms of Notch-induced Hem-pericytes growth arrest were investigated by cell cycle assay, and the role of the Notch in promoting Hem-pericyte...
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