Article

Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates

2021-12-05

Abstract excerpt

The presence of amyloid fibrils of α-synuclein is closely associated with Parkinson’s disease and related synucleinopathies. It is still very challenging, however, to systematically discover small molecules that prevent the formation of these aberrant aggregates. Here, we describe a structure-based approach to identify small molecules that specifically inhibit the surface-catalyzed secondary nucleation step in the...

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Literature Corpus work: 424923e4-407f-5f4a-9df1-6e8675d679d5
DOI: 10.1101/2021.12.05.471256

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