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Article

Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study.

BMC neurology - 21 Feb 2018

Bjørnarå Kari Anne, Pihlstrøm Lasse, Dietrichs Espen, Toft Mathias

Abstract excerpt

BACKGROUND: Parkinson's disease is a heterogeneous disorder where genetic factors may underlie clinical variability. Rapid eye movement sleep behavior disorder (RBD) is a parasomnia strongly linked to synucleinopathies, including Parkinson's disease. We hypothesized that SNCA variants conferring risk of Parkinson's disease would also predispose to an RBD phenotype. METHODS: We assessed possible RBD (pRBD) status...

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Identifiers

PMID: 29466944
DOI: 10.1186/s12883-018-1023-6
PMCID: PMC5822630

Genes

SNCA
MAPT

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