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Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

5 Dec 2022

Abstract excerpt

Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more severe subtype. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we perform a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB2. Expression...

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PMID: 36470867
DOI: 10.1038/s41467-022-34732-5

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