Article

Lack of Epistatic Interaction of<i>SNCA</i>with<i>APOE</i>in Synucleinopathies

2024-08-12

Abstract excerpt

Two recent studies suggested that the APOE ε4 haplotype was associated with increased α-synuclein pathology in cell and mouse models. Genetic variants in the SNCA region have strong association with Parkinson’s disease (PD), Dementia with Lewy Bodies (DLB), and idiopathic REM Sleep Behavior Disorder (iRBD), while APOE is a genetic risk determinant for only DLB. To determine if genetic-level interactions between SN...

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Literature Corpus work: dba0a085-9415-5348-b03a-4eec2cb74e1f
DOI: 10.1101/2024.08.12.24311821

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