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Article

A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease.

Annals of neurology - 1 Jul 2018

Pihlstrøm Lasse, Blauwendraat Cornelis, Cappelletti Chiara, Berge-Seidl Victoria, Langmyhr Margrete, Henriksen Sandra Pilar, van de Berg Wilma D J, Gibbs J Raphael, Cookson Mark R, Singleton Andrew B, Nalls Mike A, Toft Mathias

Abstract excerpt

OBJECTIVE: The goal of this study was to refine our understanding of disease risk attributable to common genetic variation in SNCA, a major locus in Parkinson disease, with potential implications for clinical trials targeting α-synuclein. We aimed to dissect the multiple independent association signals, stratify individuals by SNCA-specific risk profiles, and explore expression quantitative trait loci. METHODS:...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30146727
DOI: 10.1002/ana.25274
PMCID: PMC6192521

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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