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Article

Peripheral α-synuclein isoforms are potential biomarkers for diagnosis and prognosis of isolated REM sleep behavior disorder.

Parkinsonism & related disorders - 1 Oct 2023

Arnaldo Laura, Urbizu Aintzane, Serradell Mònica, Gaig Carles, Anillo Ana, Gea Mireia, Vilas Dolores, Ispierto Lourdes, Muñoz-Lopetegi Amaia, Mayà Gerard, Pastor Pau, Álvarez Ramiro, Santamaria Joan, Iranzo Alex, Beyer Katrin

Abstract excerpt

INTRODUCTION: Isolated REM sleep behavior disorder (IRBD) represents an early manifestation of the synucleinopathies Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Aggregation of abnormal α-synuclein and its increased expression in the brain is crucial in the development of the synucleinopathies. Whereas α-synuclein gene (SNCA) transcripts are overexpressed in brain, a concomitant reduction occurs...

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Identifiers

PMID: 37678102
DOI: 10.1016/j.parkreldis.2023.105832

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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