Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous detection of changes in protein expression and oxidative modification as a function of age and APOE genotype.

Journal of proteome research - 1 Apr 2011

DeKroon Robert M, Osorio Cristina, Robinette Jennifer B, Mocanu Mihaela, Winnik Witold M, Alzate Oscar

Abstract excerpt

To better elucidate temporal changes in protein oxidation resulting from aging and the Alzheimer's disease-associated Apolipoprotein E (ApoE), we developed a 2D-DIGE-based method for simultaneously detecting differential expression and carbonyl oxidation of proteins. Specifically, we examined changes in the levels of oxidation and total protein expression in hippocampi from young-adult (25-30 weeks) and old...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apolipoprotein E3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Mass Spectrometry

Share to Mice, Transgenic

Share to Oxidation-Reduction

Share to Principal Component Analysis

Source

Identifiers

PMID: 21210719
DOI: 10.1021/pr1009788

Genes

APOE
NHS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous detection of changes in protein expression and oxidative modification as a function of age and APOE genotype.PMID 21210719Read ↗

Proteomic analysis of serum proteins in triple transgenic Alzheimer's disease mice: implications for identifying biomarkers for use to screen potential candidate therapeutic drugs for early Alzheimer's disease.Semantic proximity Read ↗

Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.Semantic proximity Read ↗

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge.Semantic proximity Read ↗

Redox proteomics identification of oxidatively modified proteins in Alzheimer's disease brain and in vivo and in vitro models of AD centered around Aβ(1–42)☆Semantic proximity Read ↗

Discovery of plasma protein biomarkers related to Alzheimer’s disease, sex and APOE genotypeSemantic proximity Read ↗

In Vivo Metabolic Labeling with an Isoprenoid Probe Reveals APOE Allele-Specific Differences in the Prenylome.Semantic proximity Read ↗

Analysis of Brain Protein Stability Changes in a Mouse Model of Alzheimer's Disease.Semantic proximity Read ↗

Potential Alzheimer’s early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathologySemantic proximity Read ↗

Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice.Semantic proximity Read ↗

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.Semantic proximity Read ↗

Determination of malondialdehyde, reduced glutathione levels and APOE4 allele frequency in late-onset Alzheimer's disease in Denizli, TurkeySemantic proximity Read ↗

<i>In vivo</i> Protein Footprinting Reveals the Dynamic Conformational Changes of Proteome of Multiple Tissues in Progressing Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.