Article

Human enteric nervous system progenitor transplantation restores functional responses in Hirschsprung Disease patient-derived tissue

2023-11-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Hirschsprung disease (HSCR) is a severe congenital disorder affecting 1:5000 live births. HSCR results from failure of enteric nervous system (ENS) progenitors to fully colonise the gastrointestinal tract during embryonic development. This leads to aganglionosis in the distal bowel, resulting in disrupted motor activity and impaired peristalsis. Currently, the only viable treat...

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Literature Corpus work: 1e23d9c6-849a-57e8-a594-1788c02f7bb5
DOI: 10.1101/2023.11.13.23298455

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