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Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue

30 May 2024

Abstract excerpt

OBJECTIVE: Hirschsprung disease (HSCR) is a severe congenital disorder affecting 1:5000 live births. HSCR results from the failure of enteric nervous system (ENS) progenitors to fully colonise the gastrointestinal tract during embryonic development. This leads to aganglionosis in the distal bowel, resulting in disrupted motor activity and impaired peristalsis. Currently, the only viable treatment option is...

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PMID: 38816188
DOI: 10.1136/gutjnl-2023-331532

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