Article

Ischemia promotes hypertrophic nerve trunk formation and enteric neuron cell death in Hirschsprung’s disease

2024-03-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Enteric nervous system dysfunction is linked to digestive and neurological disorders. Hirschsprung’s disease (HSCR) is characterized by the loss of enteric neuron cells (ENCs) in the distal colon. Embryonic enteric neural crest cell (ENCC) migration defects contribute to HSCR development in some infants, but postnatal factors that regulate ENC fate are undetermined. We sought...

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Literature Corpus work: fca1aab9-1eb7-5051-97d6-32187a0289ec
DOI: 10.1101/2024.03.14.24304192

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