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Article

Autologous cell transplantation for treatment of colorectal aganglionosis in mice

20 Mar 2024

Abstract excerpt

Neurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the enteric nervous system (ENS) in a model of colonic aganglionosis. ENSCs are isolated from a segment of small intestine from Wnt1::Cre;R26iDTR mice in which focal colonic aganglionosis is simultaneously...

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Share to Congenital gastrointestinal and neural anomalies
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PMID: 38509106
DOI: 10.1038/s41467-024-46793-9

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