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Article

Hirschsprung disease: a developmental disorder of the enteric nervous system

24 Apr 2012

Abstract excerpt

Hirschsprung disease (HSCR), which is also called congenital megacolon or intestinal aganglionosis, is characterized by an absence of enteric (intrinsic) neurons from variable lengths of the most distal bowel. Because enteric neurons are essential for propulsive intestinal motility, infants with HSCR suffer from severe constipation and have a distended abdomen. Currently the only treatment is surgical removal of...

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PMID: 23799632
DOI: 10.1002/wdev.57

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