Article

Abrogation of RAB27A expression transiently affects melanoma cell proliferation

2019-12-27

Abstract excerpt

The role of the small GTPase RAB27A as an essential melanosome trafficking regulator in melanocytes is well-accepted. A decade ago, RAB27A was identified as a tumor dependency gene that promotes melanoma cell proliferation. RAB27A has since been linked to another propeller of cancer progression: exosome secretion. We have recently demonstrated that RAB27A is overexpressed in a subset of melanomas. High RAB27A gene...

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Literature Corpus work: 41d0dd09-0929-5df0-a4b5-f2a75d48d019
DOI: 10.1101/2019.12.27.889329

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