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Article

Ral activation promotes melanomagenesis.

Oncogene - 26 Aug 2010

Zipfel P A, Brady D C, Kashatus D F, Ancrile B D, Tyler D S, Counter C M

Abstract excerpt

Up to one-third of human melanomas are characterized by an oncogenic mutation in the gene encoding the small guanosine triphosphatase (GTPase) NRAS. Ras proteins activate three primary classes of effectors, namely, Rafs, phosphatidyl-inositol-3-kinases (PI3Ks) and Ral guanine exchange factors (RalGEFs). In melanomas lacking NRAS mutations, the first two effectors can still be activated through an oncogenic BRAF...

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Source

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Identifiers

PMID: 20562921
DOI: 10.1038/onc.2010.224
PMCID: PMC2928877

Genes

NRAS
BRAF
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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