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Article

CD271 is a molecular switch with divergent roles in melanoma and melanocyte development

22 May 2019

Abstract excerpt

Dysregulation of signaling networks controlling self-renewal and migration of developmental cell lineages is closely linked to the proliferative and invasive properties of tumors. Identification of such signaling pathways and their critical regulators is vital for successful design of effective targeted therapies against neoplastic tissue growth. The neurotrophin receptor (CD271/NGFR/p75NTR) is a key regulator of...

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PMID: 31118427
DOI: 10.1038/s41598-019-42773-y

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