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Article

RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomes

17 Dec 2018

Abstract excerpt

Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A was overexpressed in a subset of melanomas, which correlated with poor patient survival. Loss of...

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PMID: 30556600
DOI: 10.1002/ijc.32064

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