Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.

doi:10.1038/nm.2753

Article

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.

Nature medicine - 1 Jun 2012

Peinado Héctor, Alečković Maša, Lavotshkin Simon, Matei Irina, Costa-Silva Bruno, Moreno-Bueno Gema, Hergueta-Redondo Marta, Williams Caitlin, García-Santos Guillermo, Ghajar Cyrus, Nitadori-Hoshino Ayuko, Hoffman Caitlin, Badal Karen, Garcia Benjamin A, Callahan Margaret K, Yuan Jianda, Martins Vilma R, Skog Johan, Kaplan Rosandra N, Brady Mary S, Wolchok Jedd D, Chapman Paul B, Kang Yibin, Bromberg Jacqueline, Lyden David

Abstract excerpt

Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human subjects. Exosomes from highly metastatic melanomas increased the metastatic behavior of primary tumors by perm...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.

Abstract excerpt

Topics

Related research