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Article

Functional implications of Rab27 GTPases in Cancer

6 Aug 2018

Abstract excerpt

BACKGROUND: The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. MAIN BODY: Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of...

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PMID: 30081925
DOI: 10.1186/s12964-018-0255-9

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