Article

KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy

2023-08-05

Abstract excerpt

It has recently been shown that KAT8 , a genome-wide association study (GWAS) candidate risk gene for Parkinson’s Disease, is involved in PINK1/Parkin-dependant mitophagy. The KAT8 gene encodes a lysine acetyltransferase and represents the catalytically active subunit of the non-specific lethal (NSL) epigenetic remodelling complex. In the current study, we show that contrary to KAT5 inhibition, dual inhibition o...

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Literature Corpus work: 41c94bba-de7d-55f5-97d9-c7bd54ea4026
DOI: 10.1101/2023.08.03.551835

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