Article
A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death.
Archives italiennes de biologie - 1 Jan 2000
Lenzi P, Marongiu R, Falleni A, Gelmetti V, Busceti C L, Michiorri S, Valente E M, Fornai F
Abstract excerpt
Mutations in the PTEN-induced putative kinase1 (PINK1) represent the second most frequent cause of autosomal recessive Parkinson's disease. The PINK1 protein mainly localizes to mitochondria and interacts with a variety of proteins, including the pro-autophagy protein beclin1 and the ubiquitin-ligase parkin. Upon stress conditions, PINK1 is known to recruit parkin at the surface of dysfunctional mitochondria and...
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