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Article

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

1 Sept 2017

Abstract excerpt

Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with diverse pathologies, including cancer. Because the main known regulators of mitophagy are frequently inactivated in cancer cells, the mechanisms that regulate mitophagy in cancer cells are not fully understood. Here, we identified an E3 ubiquitin ligase...

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Identifiers

PMID: 28930681
DOI: 10.1016/j.celrep.2017.08.087

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