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Article

Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress

27 Aug 2025

Abstract excerpt

The PINK1/Parkin pathway targets damaged mitochondria for degradation via mitophagy. Genetic evidence implicates impaired mitophagy in Parkinson's disease, making its pharmacological enhancement a promising therapeutic strategy. Here, we characterize two mitophagy activators: a novel Parkin activator, FB231, and the reported PINK1 activator MTK458. Both compounds lower the threshold for mitochondrial toxins to...

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PMID: 40864725
DOI: 10.1126/sciadv.ady0240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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