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Article

Small Molecule Stabilization of PINK-1/PINK1 Improves Neurodegenerative Disease

2021-06-07

Abstract excerpt

Macroautophagic recycling of dysfunctional mitochondria, known as mitophagy, is essential for mitochondrial homeostasis and cell viability. Accumulation of defective mitochondria and impaired mitophagy have been widely implicated in many neurodegenerative diseases, and loss-of-function mutations of two regulators of mitophagy, PINK1 and Parkin, are amongst the most common causes of recessive Parkinson’s disease. A...

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Identifiers and source

Literature Corpus work
36899b96-7b28-5823-8d30-cb3b5de91ba7
DOI
10.1101/2021.06.07.447442
Open publication

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Small Molecule Stabilization of PINK-1/PINK1 Improves Neurodegenerative DiseaseDOI 10.1101/2021.06.07.447442
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