Accelerated single cell seeding in relapsed multiple myeloma.

doi:10.1038/s41467-020-17459-z

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Article

Accelerated single cell seeding in relapsed multiple myeloma.

Nature communications - 17 Jul 2020

Landau Heather J, Yellapantula Venkata, Diamond Benjamin T, Rustad Even H, Maclachlan Kylee H, Gundem Gunes, Medina-Martinez Juan, Ossa Juan Arango, Levine Max F, Zhou Yangyu, Kappagantula Rajya, Baez Priscilla, Attiyeh Marc, Makohon-Moore Alvin, Zhang Lance, Boyle Eileen M, Ashby Cody, Blaney Patrick, Patel Minal, Zhang Yanming, Dogan Ahmet, Chung David J, Giralt Sergio, Lahoud Oscar B, Peled Jonathan U, Scordo Michael, Shah Gunjan, Hassoun Hani, Korde Neha S, Lesokhin Alexander M, Lu Sydney, Mailankody Sham, Shah Urvi, Smith Eric, Hultcrantz Malin L, Ulaner Gary A, van Rhee Frits, Morgan Gareth J, Landgren Ola, Papaemmanuil Elli, Iacobuzio-Donahue Christine, Maura Francesco

Abstract excerpt

Multiple myeloma (MM) progression is characterized by the seeding of cancer cells in different anatomic sites. To characterize this evolutionary process, we interrogated, by whole genome sequencing, 25 samples collected at autopsy from 4 patients with relapsed MM and an additional set of 125 whole exomes collected from 51 patients. Mutational signatures analysis showed how cytotoxic agents introduce hundreds of...

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Identifiers

PMID: 32680998
DOI: 10.1038/s41467-020-17459-z
PMCID: PMC7368016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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