Article
Investigation of the relationship between prostate cancer and MSMB and NCOA4 genetic variants and protein expression.
Human mutation - 1 Jan 2013
FitzGerald Liesel M, Zhang Xiaotun, Kolb Suzanne, Kwon Erika M, Liew Ying Ching, Hurtado-Coll Antonio, Knudsen Beatrice S, Ostrander Elaine A, Stanford Janet L
Abstract excerpt
Two genome-wide association studies (GWAS) identified the β-microseminoprotein (MSMB) promoter SNP, rs10993994:C>T, as significantly associated with prostate cancer (PC) risk. Follow-up studies demonstrate that the variant allele directly affects expression of the MSMB-encoded protein, PSP94, and also suggest that it affects mRNA expression levels of an adjacent gene, NCOA4, which is involved in androgen receptor...
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