Article
Mutation analysis of the MSMB gene in familial prostate cancer.
British journal of cancer - 19 Jan 2010
Kote-Jarai Z, Leongamornlert D, Tymrakiewicz M, Field H, Guy M, Al Olama A A, Morrison J, O'Brien L, Wilkinson R, Hall A, Sawyer E, Muir K, Hamdy F, Donovan J, Neal D, Easton D, Eeles R
Abstract excerpt
BACKGROUND: MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant. The MSMB protein is underexpressed in PrCa and it was previously proposed to be an independent...
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