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Impact of Subcutaneous Versus Orthotopic Implantations on Patient-Derived Xenograft Transcriptomic Profiles

1 May 2025

Abstract excerpt

Patient-derived xenografts (PDX) are essential preclinical models, capturing the histologic and molecular features of human tumors. Subcutaneous (s.c.) and orthotopic (ortho) PDXs are widely used, but their comparative utility remains unclear, especially regarding tumor and stromal gene expression. This study analyzed 45 matched s.c. and ortho PDX models spanning five cancer types using bulk RNA sequencing. Tumor...

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PMID: 40353760
DOI: 10.1158/2767-9764.crc-25-0008

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